Helen Mirren stars as Patricia Highsmith in the film A Talent for Murder, under the direction of Anton Corbijn. Critics have described her performance as viperous and spiky. Mirren has called Highsmith the hardest real person she has ever portrayed, highlighting her rough character.

Mirren and Brosnan stood up for actor Tom Hardy following gossip about issues during the filming of MobLand. She spoke about the role at the Toronto International Film Festival.